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http://www.animal-health-online.de/news/...20060115-00002/
Katzen vermehren H5N1 -Virus in vielen Organen +++ neue Infektionswege möglich
- 15.01.2006
--------------------------------------------------------------------------------
Rotterdam (aho) - Katzen, denen mit dem H5N1 - Vogelgrippevirus
infiziertes Geflügel gefüttert wird, vermehren das Virus nicht nur in
der Lunge sondern auch in anderen Organen. Wissenschaftler der
Erasmusuniversität berichten jetzt in der Fachzeitschrift "American
Journal of Pathology", dass es ihnen gelungen ist, das H5N1 - Virus
nach der Infektion im den Geweben der Atemwege, der Lunge, des Darms,
der Leber, den Nieren, im Herzen, im Gehirn und den Lymphknoten
nachzuweisen. Dabei war es unerheblich, ob die Katzen mittels
infiziertem Geflügel über die Fütterung oder untereinander von Katze
zu Katze infiziert wurden. Die Tiere hatten Fieber, waren lethargisch
und ausgeprägte Atembeschwerden.
Die Wissenschaftler schließen aus ihren Untersuchungen, dass bei der
Übertragung von Influenzaviren bei Säugetieren inklusive Menschen auch
andere Übertragungswege als die Atemwege in Betracht gezogen werden
müssen. Offensichtlich kann das Virus z.B. auch über Kot und Urin
ausgeschieden werden.
Guus F. Rimmelzwaan, Debby van Riel, Marianne Baars, Theo M. Bestebroer,
Geert van Amerongen, Ron A.M. Fouchier, Albert D.M.E. Osterhaus, and
Thijs Kuiken
Influenza A Virus (H5N1) Infection in Cats Causes Systemic Disease
with Potential Novel Routes of Virus Spread within and between Hosts
Am J Pathol 2006 168: 176-183.
Dies wird durch Promed bestätige, bzw. die AHO hats wohl von dort:
http://www.promedmail.org/pls/promed/f? ...L_ID:1000,31645
Archive Number 20060114.0140
Published Date 15-JAN-2006
Subject PRO/AH> Avian influenza, cats: H5N1 systemic infection
AVIAN INFLUENZA, CATS: H5N1 SYSTEMIC INFECTION
**********************************************
A ProMED-mail post
ProMED-mail is a program of the
International Society for Infectious Diseases
Date: Sat 14 Jan 2006
From: Joseph Dudley
Source: American Journal of Pathology, Fri 13 Jan 2006, via
EurekAalert, Sat 14 Jan 2006 [edited]
Avian influenza virus in mammals spreads beyond the site of infection
to other organ systems
---------------------------------------------------
Researchers at the Erasmus Medical Center have demonstrated systemic
spread of avian influenza virus in cats infected by respiratory,
digestive, and cat-to-cat contact. The paper by Rimmelzwaan et al.,
"Influenza A virus (H5N1) infection in cats causes systemic disease
with potential novel routes of virus spread within and between
hosts," appears in the January issue of The American Journal of
Pathology and is accompanied by a commentary.
Avian influenza (H5N1) is of great concern because of the current
outbreaks in Asia and the potential for pandemic spread. This virus
is highly contagious in birds and spreads easily due to the
agricultural and migratory nature of the bird species infected,
including poultry, waterfowl, and other migratory species (See
commentary by Brown for more information). While spread of avian
influenza from bird to man is known to occur, as first reported
during the 1997 Hong Kong outbreak, human-to-human spread is
extremely rare. Thus, the disease events that take place during
mammal-to-mammal spread are not well characterized.
To assess the spread of H5N1 influenza virus in mammalian hosts,
Rimmelzwaan et al. examined cats infected via the respiratory tract,
via the digestive tract (by feeding on infected chicks), or by close
contact with respiratory-infected cats. The researchers, led by Dr.
Thijs Kuiken, then examined mucous membranes (throat, nasal, and
rectal swabs) and organ systems (respiratory, digestive, nervous,
cardiovascular, urinary, lymphoid, and endocrine) for the presence of
virus and viral protein.
As expected, all cats were infected with H5N1 virus and exhibited
clinical signs of disease (fever, lethargy, labored breathing, etc.),
and virus was detected in throat, nasal, and rectal swabs, regardless
of the original site of infection. Most interesting, virus spread
throughout the organ systems with virus being found in respiratory
and digestive tracts, liver, kidney, heart, brain, and lymph nodes.
Furthermore, examination of infected tissues revealed cellular damage
at sites containing viral proteins, providing an explanation for the
increased severity of disease in humans.
These data underscore the potential for influenza virus to spread not
only from the respiratory tract but also from the digestive and
urinary tracts, greatly increasing the possible routes of mammalian
transmission. Systemic disease has long been known to occur in birds,
with the fecal-oral route of transmission being most important.
However, this is the 1st demonstration of systemic replication in
cats, providing a cautionary tale for humans regarding how influenza
is spread and how the disease presents itself.
Rimmelzwaan and colleagues caution that because of the systemic
nature of avian influenza, "H5N1 virus infection needs to be included
in the differential diagnosis of a broader range of clinical
presentations than is currently done." In addition better
understanding of the mechanisms of spread, including possible
fecal-oral route in humans, "may limit the risk of H5N1 virus
developing into a pandemic influenza virus."
(This work was performed at the Department of Virology, Erasmus
Medical Center, Rotterdam, The Netherlands, and was supported by a
Novaflu EU grant. The reference for the published text is:
"Rimmelzwaan GF, van Riel D, Baars M, Bestebroer TM, van Amerongen G,
Fouchier RAM, Osterhaus ADME, and Kuiken T: Influenza A virus (H5N1)
infection in cats causes systemic disease with potential novel routes
of virus spread within and between hosts. Am J Pathol 2006 168:
176-183". The paper is accompanied by a Commentary by C.Brown: Avian
influenza: Virchow's reminder. Am J Pathol 2006 168: 6-8.)
--
Joseph P. Dudley, Ph.D
Research Associate
Institute of Arctic Biology - University of Alaska Fairbanks
Department of Earth Science - University of Alaska Museum
[The susceptibility of carnivores to avian influenza A virus was
first recorded in a paper published in the China Journal of
Veterinary Science in 2003, demonstrating that tigers had died of
influenza A virus infection in China in 2002.
Subsequently in 2004 during the H5N1 avian influenza outbreak in
Thailand considerable mortality occurred among zoo tigers and
leopards probably as a result of ingestion of diseased poultry. More
recently, deaths of chickens and dogs were reported in a rural
village (Bozkurt) in Turkey, although the cause was not determined.
Now Rimmelzwaan et al. have used domestic cats as a model to
investigate factors affecting the spread of avian influenza A viruses
from mammal to mammal. Their data clearly demonstrate systemic spread
of virus in cats and multiplication of virus in several organ
systems. The wider importance of their findings resides in their
final conclusion: "....better understanding of the mechanisms of
spread, including possible fecal-oral route in humans, "may limit the
risk of H5N1 virus developing into a pandemic influenza virus." - Mod.CP]
[see also:
Avian influenza, human - Eurasia (05): Turkey: 20060108.0062
2004
----
Avian influenza, Eastern Asia (130): China, tigers 20041023.2873
Avian influenza, Eastern Asia (134): Thailand, tig... 20041102.2965
Avian influenza, Eastern Asia (139): Thailand, tig... 20041120.3111
Avian influenza, cats: H5N1 susceptibility 20040903.2464
Avian influenza - Eastern Asia (7 : Thailand, cats 20040617.1614
Avian influenza - Eastern Asia (26) 20040216.0510]
...............cp/pg/mpp
*##########################################################*
************************************************************
ProMED-mail makes every effort to verify the reports that
are posted, but the accuracy and completeness of the
information, and of any statements or opinions based
thereon, are not guaranteed. The reader assumes all risks in
using information posted or archived by ProMED-mail. ISID
and its associated service providers shall not be held
responsible for errors or omissions or held liable for any
damages incurred as a result of use or reliance upon posted
or archived material.
************************************************************
Please support ProMED-mail by donating to the 2005 Internet-
a-thon at
************************************************************
Visit ProMED-mail's web site at .
Send all items for posting to: **********
(NOT to an individual moderator). If you do not give your
full name and affiliation, it may not be posted. Send
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etc. to: **********. For assistance from a
human being send mail to: **********.
############################################
Bleibt abzuwarten, ob wir nun das Geflügel zum Schutz der Katzen keulen müssen, oder ob wir auch Katzen einsperren und somit eine größere Lobby für den Schutz unserer Tiere erreichen
Vielleicht hat unsere Regierung schonen einen Plan, absofort sind alle Katzen zu töten, aufzustallen um sie für die humane Keulung bereit zu halten?
Übrigens ich bin nicht nur Federfreund, mich besitzen auch 3 Katzen.
__________________
http://www.animal-health-online.de/news/...20060115-00002/
Katzen vermehren H5N1 -Virus in vielen Organen +++ neue Infektionswege möglich
- 15.01.2006
--------------------------------------------------------------------------------
Rotterdam (aho) - Katzen, denen mit dem H5N1 - Vogelgrippevirus
infiziertes Geflügel gefüttert wird, vermehren das Virus nicht nur in
der Lunge sondern auch in anderen Organen. Wissenschaftler der
Erasmusuniversität berichten jetzt in der Fachzeitschrift "American
Journal of Pathology", dass es ihnen gelungen ist, das H5N1 - Virus
nach der Infektion im den Geweben der Atemwege, der Lunge, des Darms,
der Leber, den Nieren, im Herzen, im Gehirn und den Lymphknoten
nachzuweisen. Dabei war es unerheblich, ob die Katzen mittels
infiziertem Geflügel über die Fütterung oder untereinander von Katze
zu Katze infiziert wurden. Die Tiere hatten Fieber, waren lethargisch
und ausgeprägte Atembeschwerden.
Die Wissenschaftler schließen aus ihren Untersuchungen, dass bei der
Übertragung von Influenzaviren bei Säugetieren inklusive Menschen auch
andere Übertragungswege als die Atemwege in Betracht gezogen werden
müssen. Offensichtlich kann das Virus z.B. auch über Kot und Urin
ausgeschieden werden.
Guus F. Rimmelzwaan, Debby van Riel, Marianne Baars, Theo M. Bestebroer,
Geert van Amerongen, Ron A.M. Fouchier, Albert D.M.E. Osterhaus, and
Thijs Kuiken
Influenza A Virus (H5N1) Infection in Cats Causes Systemic Disease
with Potential Novel Routes of Virus Spread within and between Hosts
Am J Pathol 2006 168: 176-183.
Dies wird durch Promed bestätige, bzw. die AHO hats wohl von dort:
http://www.promedmail.org/pls/promed/f? ...L_ID:1000,31645
Archive Number 20060114.0140
Published Date 15-JAN-2006
Subject PRO/AH> Avian influenza, cats: H5N1 systemic infection
AVIAN INFLUENZA, CATS: H5N1 SYSTEMIC INFECTION
**********************************************
A ProMED-mail post
ProMED-mail is a program of the
International Society for Infectious Diseases
Date: Sat 14 Jan 2006
From: Joseph Dudley
Source: American Journal of Pathology, Fri 13 Jan 2006, via
EurekAalert, Sat 14 Jan 2006 [edited]
Avian influenza virus in mammals spreads beyond the site of infection
to other organ systems
---------------------------------------------------
Researchers at the Erasmus Medical Center have demonstrated systemic
spread of avian influenza virus in cats infected by respiratory,
digestive, and cat-to-cat contact. The paper by Rimmelzwaan et al.,
"Influenza A virus (H5N1) infection in cats causes systemic disease
with potential novel routes of virus spread within and between
hosts," appears in the January issue of The American Journal of
Pathology and is accompanied by a commentary.
Avian influenza (H5N1) is of great concern because of the current
outbreaks in Asia and the potential for pandemic spread. This virus
is highly contagious in birds and spreads easily due to the
agricultural and migratory nature of the bird species infected,
including poultry, waterfowl, and other migratory species (See
commentary by Brown for more information). While spread of avian
influenza from bird to man is known to occur, as first reported
during the 1997 Hong Kong outbreak, human-to-human spread is
extremely rare. Thus, the disease events that take place during
mammal-to-mammal spread are not well characterized.
To assess the spread of H5N1 influenza virus in mammalian hosts,
Rimmelzwaan et al. examined cats infected via the respiratory tract,
via the digestive tract (by feeding on infected chicks), or by close
contact with respiratory-infected cats. The researchers, led by Dr.
Thijs Kuiken, then examined mucous membranes (throat, nasal, and
rectal swabs) and organ systems (respiratory, digestive, nervous,
cardiovascular, urinary, lymphoid, and endocrine) for the presence of
virus and viral protein.
As expected, all cats were infected with H5N1 virus and exhibited
clinical signs of disease (fever, lethargy, labored breathing, etc.),
and virus was detected in throat, nasal, and rectal swabs, regardless
of the original site of infection. Most interesting, virus spread
throughout the organ systems with virus being found in respiratory
and digestive tracts, liver, kidney, heart, brain, and lymph nodes.
Furthermore, examination of infected tissues revealed cellular damage
at sites containing viral proteins, providing an explanation for the
increased severity of disease in humans.
These data underscore the potential for influenza virus to spread not
only from the respiratory tract but also from the digestive and
urinary tracts, greatly increasing the possible routes of mammalian
transmission. Systemic disease has long been known to occur in birds,
with the fecal-oral route of transmission being most important.
However, this is the 1st demonstration of systemic replication in
cats, providing a cautionary tale for humans regarding how influenza
is spread and how the disease presents itself.
Rimmelzwaan and colleagues caution that because of the systemic
nature of avian influenza, "H5N1 virus infection needs to be included
in the differential diagnosis of a broader range of clinical
presentations than is currently done." In addition better
understanding of the mechanisms of spread, including possible
fecal-oral route in humans, "may limit the risk of H5N1 virus
developing into a pandemic influenza virus."
(This work was performed at the Department of Virology, Erasmus
Medical Center, Rotterdam, The Netherlands, and was supported by a
Novaflu EU grant. The reference for the published text is:
"Rimmelzwaan GF, van Riel D, Baars M, Bestebroer TM, van Amerongen G,
Fouchier RAM, Osterhaus ADME, and Kuiken T: Influenza A virus (H5N1)
infection in cats causes systemic disease with potential novel routes
of virus spread within and between hosts. Am J Pathol 2006 168:
176-183". The paper is accompanied by a Commentary by C.Brown: Avian
influenza: Virchow's reminder. Am J Pathol 2006 168: 6-8.)
--
Joseph P. Dudley, Ph.D
Research Associate
Institute of Arctic Biology - University of Alaska Fairbanks
Department of Earth Science - University of Alaska Museum
[The susceptibility of carnivores to avian influenza A virus was
first recorded in a paper published in the China Journal of
Veterinary Science in 2003, demonstrating that tigers had died of
influenza A virus infection in China in 2002.
Subsequently in 2004 during the H5N1 avian influenza outbreak in
Thailand considerable mortality occurred among zoo tigers and
leopards probably as a result of ingestion of diseased poultry. More
recently, deaths of chickens and dogs were reported in a rural
village (Bozkurt) in Turkey, although the cause was not determined.
Now Rimmelzwaan et al. have used domestic cats as a model to
investigate factors affecting the spread of avian influenza A viruses
from mammal to mammal. Their data clearly demonstrate systemic spread
of virus in cats and multiplication of virus in several organ
systems. The wider importance of their findings resides in their
final conclusion: "....better understanding of the mechanisms of
spread, including possible fecal-oral route in humans, "may limit the
risk of H5N1 virus developing into a pandemic influenza virus." - Mod.CP]
[see also:
Avian influenza, human - Eurasia (05): Turkey: 20060108.0062
2004
----
Avian influenza, Eastern Asia (130): China, tigers 20041023.2873
Avian influenza, Eastern Asia (134): Thailand, tig... 20041102.2965
Avian influenza, Eastern Asia (139): Thailand, tig... 20041120.3111
Avian influenza, cats: H5N1 susceptibility 20040903.2464
Avian influenza - Eastern Asia (7 : Thailand, cats 20040617.1614
Avian influenza - Eastern Asia (26) 20040216.0510]
...............cp/pg/mpp
*##########################################################*
************************************************************
ProMED-mail makes every effort to verify the reports that
are posted, but the accuracy and completeness of the
information, and of any statements or opinions based
thereon, are not guaranteed. The reader assumes all risks in
using information posted or archived by ProMED-mail. ISID
and its associated service providers shall not be held
responsible for errors or omissions or held liable for any
damages incurred as a result of use or reliance upon posted
or archived material.
************************************************************
Please support ProMED-mail by donating to the 2005 Internet-
a-thon at
************************************************************
Visit ProMED-mail's web site at .
Send all items for posting to: **********
(NOT to an individual moderator). If you do not give your
full name and affiliation, it may not be posted. Send
commands to subscribe/unsubscribe, get archives, help,
etc. to: **********. For assistance from a
human being send mail to: **********.
############################################
Bleibt abzuwarten, ob wir nun das Geflügel zum Schutz der Katzen keulen müssen, oder ob wir auch Katzen einsperren und somit eine größere Lobby für den Schutz unserer Tiere erreichen
Vielleicht hat unsere Regierung schonen einen Plan, absofort sind alle Katzen zu töten, aufzustallen um sie für die humane Keulung bereit zu halten?
Übrigens ich bin nicht nur Federfreund, mich besitzen auch 3 Katzen.
__________________